SAMe

=Other Names= S-adenosyl-L-Methioine, adenosylmethionine

=Generalities= This molecule is made naturally by the body. It is derived from the amino acid methionine and from adenosine triphosphate (ATP- the source of cellular energy)

=Properties= -Plays an essential role in the cycle of glutathione, a very powerful antioxidant made by the body -Precursor of many essential amino acids (see methionine) -Contributes to the synthesis, activation and metabolism of hormones, neurotransmitters, proteins, etc. -Essential for the proper functioning of the body, particularly the central nervous system and the liver

=Therapeutic Indications= -Arthrosis -Depression -Fibromyalgia -Cirrhosis of the liver -Hepatitis -Biliary cholestasis in pregnant and post-partum women

=Contraindications= -Manic-depressive psychosis

=Precautions= As SAMe is an unstable molecule, it is essential to choose enteric coated capsules that come in blister packs

=Food Sources= Methionine is found in meat, fish and milk products Supplements: from synthetic sources (s-adrenosylmethionine-bisulfate-tosylate)

=Therapeutic Dose= Arthrosis: From 600-1200mg./day for the first 2 weeks, then reduce to 400mg./day thereafter

Depression: 800-1600mg/day