Lyme+Disease

-stage 1 is primary Lyme disease - early localized disease -stage 2 is secondary Lyme disease - early disseminated disease, follows stage 1 by days to months -stage 3 is tertiary Lyme disease - late Lyme disease, persistent infection, follows stage 2 by months to years -"chronic Lyme disease" is a misnomer and should not be used as a diagnosis (N Engl J Med 2007 Oct 4;357(14):1422), correction can be found in N Engl J Med 2008 Mar 6;358(10):1084, commentary can be found in N Engl J Med 2008 Jan 24;358(4):428  stage 1 - local spread in skin  stage 2 - skin, heart (atrioventricular dissociation may last 1-2 weeks then resolve), joints, lymphatics, eyes, liver, respiratory system, kidney, CNS astroglia  stage 3 - joints, skin, CNS, eye  > 90% cases have occurred in  o northeastern coastal states (from Massachusetts to Virginia) o upper Midwest (especially Wisconsin and Minnesota) o northern California (and Oregon, spread with bird migration) Toll like receptors (TLRs) - Detect pathogens Missing in Lyme patients – Upregulated by D, Butyrate and L. acidophilus
 * Organs Involved:**
 * Who is most affected:**

**-Etiology**:
Originally thought to be caused by a deer tick (Ixodes) bite. It was named after an initial cluster of children in Lyme Connecticut who developed juvenile rheumatoid arthritis in 1975. A tick bite infected with the spirochete Borrelia burgdorferi (Bb) causes a rash called erythema migrans (EM), which means chronic migrating red rash. 90% of people initially experience the rash, which occurs about 7 days after a bite (Range: 3-30 days). The spirochete can burrow into tendons, muscles, ligaments, and directly into organs and causing varying symptoms (months to years later) in late stage disease. These can be neurologic in 15%, cardiovascular in 8% (__Clinical Dermatology__ Habif 2004) and then some can have many “disease states” like ALS, Parkinson’s, MS, bells palsy, reflex sympathetic dystrophy, neuritis, psychiatric illnesses like schizophrenia, chronic fatigue, heart failure and angina, arrhythmias, fibromyalgia, dermatitis, autoimmune diseases like scleroderma and lupus, eye inflammation, sudden deafness, SIDS, ADD, and ADHD, chronic pain, Erythema nodosum, and more. One study found that every ALS, Alzheimer’s, Parkinson’s and MS patient was positive for Lyme, while positives in the general population were 1/23 people tested. (Science Nov 9, 2001) A growing group of health care practitioners are convinced that Lyme is much more extensive than is thought in conservative literature. It is still very controversial with a variety of different diagnostic tests being used by different Doctors. (Townsend Letter July 2004 p64-67 and 72-77) There are other concomitant infections that can occur- Erlichiosis in WBCs and Babesia in RBCs. Babesiosis is difficult to treat but seems to respond to Artemesin. It may be necessary to treat Babesiosis first. Classically, in the conservative literature, the highest risk locations for the tick bites are in Conn, RI, NY, NJ, Delaware, Penn, Maryland and Wisconsin. It occurs in people walking with shorts in the woods or barefoot, especially in fall or late summer. It also occurs in Europe and the symptoms can be somewhat different with more prominent skin involvement. Habif Biology professor, Lida Mattman PH.D., author of __Cell Wall Deficient Forms: Stealth Pathogens,__ has isolated live Bb from mosquitoes, fleas, ticks, semen, urine, blood and spinal fluid. Bb can replicate without its cell wall, which makes it not treatable by many antibiotics. Spread of Lyme is now thought to not just be tick born. One in fifteen has the disease, and 18 to 20 million Americans are thought to be infected. (Townsend Letter July 2004 p64-67 and 72-77)

**-Diagnosis:**
The Elisa, Western Blot test is an antibody assay, which can be falsely negative or positive. The patient can be negative with the Elisa, PCR and positive on the (Qualitative rapid immunofluorescent antibody for Borrelia Burgdorferi -QRIBb), developed by Joanne Whitaker MD.
 * (**Originally) bull’s eye lesion around a deer tick bite, followed by a fairly severe flu with a fever, joint aches and malaise. If not treated promptly with antibiotics (Doxycycline 100 mg PO BID x 21 days) it can progress to chronic Lyme with its large variety of symptoms.

**Treatment:**
I believe I have treated many neurological and CFIDS/Fibromyalgia patients with Lyme disease. Kids sxs: Spacey, autism Headache, seizures, fatigue, joint pain… I have been testing it in the last 3 years with the Igenex lab test, which measures antibodies, the PCR test that measures Lyme DNA presence, and the QRIBb test. I liked the QRIBb, because it has been confirmed that Dr. Whitaker’s test is sensitive to Lyme even in its non-cell membrane state and this test was confirmed by Dr. Lida Mattman’s positive histological evaluation 100% of the time. It is no longer available. (TLJuly 2004 p. 65)

-**Tx Choices**: antibiotics (PARS conference) TOA (Tertracyclic Oxindole Alkaloid) is a alkaloid in cat’s claw herb from Peru that interferes with the cat’s claw’s ability to kill Lyme disease. POA (Pentacyclic) cat’s claw kills Lyme as well as has an immune modulating effect. [Nutrimetics is a sustainable source] Samento is also used by tribes is the Amazon for gastritis, colitis, ulcers, diverticulitis, leaky gut and hemorrhoids. It is anti-inflammatory, lowers BP, and opens up peripheral vasculature. It normalizes cardiac function and cholesterol.
 * Samento** –Non-TOA cat’s claw with enzymes to avoid worsening of symptoms with a Herxheimer. reaction.

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TCM
– Leptospira: Isatis leaf, Smilax, Isatis root, Gardenia, Andrographis, Hu-chang, Coptis, Chien-li-kuang, Scute, Verbena, Phellodendron, Sanguisorba, Forsythia, Ching-hao Anti-Spirochete Mixture (equal parts) Smilax, Ching-hao, Forsythia, Hu-chang, Andrographis, Lonicera stem

**1. Wind Damp Heat Evil Toxin:**  Rash, fever, chills, wind aversion, muscle joint pain and dryness liking cold drinks,  Stage 1 - treatment of early Lyme disease (erythema migrans)
 * Tongue:** Red and slimy yellow fur
 * Pulse:** Floating, bowstring, fast and slippery
 * Herbs:** Pu Gong YI, Jin Yin Hua - Lonicera, Zi Hua Di Ding – Viola, Fu Ling – Poria, Che qian Zi- Plantain, Ye Ju Hua – Chrysanthemum, Niu Zi – Achyranthis, Tian Kui zi – Semiaquilegia
 * Acupuncture:** Li11, Sp10, GB31, Bl40 (St36, GV10, Sp9)

Swelling heat, pain in joints, sometimes red, Marked fatigue Stage 2: skin, heart (atrioventricular dissociation may last 1-2 weeks then resolve), joints, lymphatics, eyes, liver, respiratory system, kidney, CNS astroglia
 * 2. Heat Toxin with righteous Qi deficient:**
 * Tongue:** Tender light red swollen, yellow slime
 * Pulse:** Rapid surging
 * -Herbs:** Shu Di, Huang Qi, Jin Yin Hua, Mai Dong, Qiang Huo – Noptoryg., Fang Feng, Fang Ji – Steph., DQ, Huang Qin, Dang Shen - Codonopsis, Zhu Ling – Polypore, Niu Zi – Achyranthis, Huang Bai – Phel., Zhi zi - Gard, Chen Pi, Gan cao, Huang Lian – Coptis.
 * -Points:** Li11, Sp9, St36 (St 7, GV20, TW17, …)

Fatigue, Lassitude, dizzy, tinnitus, lumbar and knee pain, Swollen hot, pain, dry mouth, throat, flush, afternoon tidal fever, Vexatious heat – five hearts,
 * 3. Qi and Yin Xu with Lingering Damp Heat Evil:**
 * T:** Red, swollen, scanty fur, dry
 * P:** Fine, rapid, bowstring
 * -**stage 3 - joints, skin, CNS, eye
 * -Herbs:** Shu Di, Huang Qi, Ge Gen, Dang Shen, DQ, Zhi Mu, Huang Bai – Phell., Ku Shen, Yin Chen Hao – Artem., Qiang Huo – Noptoryg., Fang Feng, Bai Zhu, Cang Zhu, Mu Gua, Fu Ling, Ze Xie – Alisma, Gan Cao, Sheng Ma
 * -Acupuncture:** Bl17, 18, 20, 21, & 23


 * Heiner’s herbs: Thunder pearls,**
 * Consider teasel, (Dipsacus – Chuan Xin Lian - esp. in children), Andrographis -Xu duan, Berberine, SilverSol, Shao Chai Hu tang,**
 * Can add:** -**Blood type/hypoallergenic diet/low glycemic** load diet (high insulin increases inflammation) (J Royal Soc of Med2002;42)

-**Enzymes** reduce inflammatory die-off symptoms that might be seen from the Samento treatment. They make a dramatic difference if patients are having nausea and malaise. 1-2 between meals reduces inflammation. [Satya: usually trypsin & kinotrypsin]

-**Magnesium** reduces muscle spasms, headaches and Fibromyalgia pains. Aspartate and Glycinate forms don’t cause diarrhea like other forms of magnesium. Consider: “pH balancing, Probiotics to support gut flora and TH1 immunity, glutathione, L-Carnitine and Co-Q10 for neurological symptoms, Lionsmane, vitamins with no iron, B12 sublingual, cellular energy, adrenal support, nervous fatigue. (From study done by J. Whitaker – Allergy research labs.com)

-Ped RA: Jin Yin Hua, Diu Gu Pi, Shen Di, Shi Hu –Dendrob, Bai Wei – Cynanchi Atrati, Dan Pi – Moutan, Qin Jiao – Gentian, Wei Ling Xian – Clematis, Di Long – Pheretima p224