Metabolism

• Is chemical changes that occur with nutrients when absorbed into the blood. • It includes making fats, glucose and protein into ATP as well as making hormones, glycogen for storage of glucose, and getting rid of cellular metabolites- waste products. • The cellular waste products should be excreted into the extra cellular fluid, then to the blood, to the lungs, kidneys or intestines. • This chemical chain reaction utilizes many nutrients that if they are not there, will cause disease. • O3FA, L-Carnitine, Mg++, BVit … Almost all the CO2 is excreted thru the lungs and 10% of the H2O • The kidneys- filter incredible amounts of waste. Keeping what we need and letting go of what we don’t. They are especially sensitive to heavy metals binding to the tubules disrupting filtering capacity. • The skin- can let go of toxic waste if needed, electrolytes are also lost with the process of sweating, as are many toxic products stored in our fats. • The feces get rid of waste like excess fiber, fats, iron, calcium…The intestine cells replicate every 3 days and require intact absorption and repair to remake. This intestinal cellular repair is disrupted by anything that disrupts cellular replication, like the chemotherapy drugs. We need specific nutrients like glutamine to assist colon cell repair. • Urine excretes BVit, and urea from protein metabolism • Lungs

• The Liver filters blood coming from the GI tract as well as anything in the blood that is kept after going thru the various body excretory pathways. • Thousands of metabolic pathways are promulgated in the liver. • After it modifies the contents of the blood, it goes to the heart to be sent throughout the body for further metabolism. • IGF Insulin-like growth factors helps peripheral blood sugars get utilized by tissues. IGF is high in children, athletes, and people with lower blood sugar. IGF is made in the liver in the presence of insulin and growth hormone. It instigates tissue healing/replication and initiates formation of the intimal glycos-amino-glycans that protect the arteries preventing atherosclerosis. This is an anabolic factor. • GAGs- glycos-amino-glycans line the blood vessels protecting them from harm. If non-inflammatory cytokines are circulating, plus IGF, the blood vessel linings stay healthy, flexible and clear. If inflammatory processes are occurring in the GI tract or other parts of the body, this can initiate atherosclerotic disease. (Via TNFa, IL1and IL6) • ANABOLIC is a term designated to describe the building processes of metabolism. It includes structure, storage and functional processes • CATABOLIC is a term meaning breakdown processes of the body. This includes digestion, as well as, physical remodeling and aging. This includes the process of making energy out of fats and proteins. Pulling things apart so that we can make enzymes…

• -Arachidonic acid increases (inc) – uncouples Complex1,2,3 in the electron transport chain reducing Qi -“uncouples oxidative phosphorylation” reducing ATP production (Kreb’s cycle) • -This increases glycolysis increasing adrenal stress increases in cortisol. • -Inflammation in the gut (GALT) plus adrenal stressincreases antigen/antibody production  Autoimmune/CVD/Alzheimer’s/DM • -Bad gut bugs –Strept, Klebsiella, Bacteroides, Parasites, & Yeast… induce B Lymph dominance  TH2 • -Bad gut bugs make glucuronidase that remove the bile salts from estrogen and DHT, they get reabsorbed. Increased cancer

• -LPS from pathogenic gut bugs changes liver detox pathways so that Hydroxy estrogens 4 and 16 are made not E-OH2- Inc. Br CA • -No conversion by gut bugs of genistein and diadzen to useful isoflavones (SERMs)- to reduce estrogen activity  Increased E2 activity • Also-Less production of serotonin by the gut (99% made in the gut) inc depression, anxiety and irritability.-(SSRI affect gut function Side-effects) • Thyroid /Sulfation pathway in gut converts T4 T3 -Change diet dramatic mood changes(allergens/metabolism/NTs/ estrogen /gut bugs)