Coenzyme+Q10

=Other Names= CoQ10, ubiquinone

=Generalities= This antioxidant is fat soluble. It is found in all cells, hence it's name 'ubiquinone' It has a quinone action

=Properties= -Antihypertensive -Antioxidant -Lipopenic -Stimulates the immune system Stimulates mitochondrial respiration (production of APT or cellular energy)

=Co-Factors= Vitamins B2, B3, B5, B6, B9, B12 and C as well as many trace elements

=Therapeutic Indications= -Cardiovascular dis-ease -Attenuates the toxic effects of chemotherapy -Cancer (prevention)

=Contraindications and Precautions= Must be administered under medical supervision.

=Precautions and Side Effects= Causes few side effects and the one's it does are not serious. Over 600mg/day can cause headache, skin breakouts and gastric problems

=Interactions= Cholesterol-lowering medications (statins) reduce the amount of available co-Q10 as do beta-blockers, antipsychotic medication from the phenothiazine family, tricyclic antidepressants and antihypertensives. People suffering from hypercholesterolemia, hypertension or depression at the same time, who are taking medication and have problems w/ heart failure can absolutely benefit from co-Q10 supplementation. There is a theoretical interaction between coumadin and co-Q10, as the latter is a part of the same family as Vitain K, which is contrac-indicated in those taking anticoagulants

=Food Sources= -Fish Liver -Giblets -Whole Grains

=Therapeutic Dose= Preventative antioxidant: 30-90mg./day Cardopathies: 90-150mg./day Use a fat-soluble form for better bio-availability

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• Cofactor in electron transport chain, all ATP production in body depends on it. Deficiencies occur in the most metabolically active tissues. • Cardio: CHF 100- 300mg, Cardiomyopathy, Adriamycin induced cardiomyopathy – 100mg prevents, angina 150mgincreased exercise tolerance, double blind study reduced angina 53%. Gaby 2007 • HBP 60-200mg takes 1-4 months, significant reductions systolic and dystolic • Careful withdrawl • Periodontal disease 30 mg bid 3 weeks

• Aids 200mg/d increase TH1 • Breast cancer 290mg/d • Muscular dystrophy • Migraines 150mg 3mo 63% reduction (321 patients) • Parkinson’s • Familial cerebellar ataxia • Interactions: Adriamycin, lovastatin, HMGCoA inhibitors, gemfibrozil, betablockers, Tricyclic antidepressants, and phenothiazines may reduce CoQ10. ?Warfarin – but small study showed no interaction.