Acute+Nephritic+Syndrome

//Western Diagnosis// A. acute GN, postinfectious GN B. inflammatory changes in the glomeruli

Etiology
1. group A, beta-hemolytic streptococci ---ag-ab complexes deposited in glomerular walls 2. bacterial endocarditis, pneumonia, varicella, visceral abscesses, SLE, HBV, syphilis, malaria

Signs & Symptoms
1. PSGN most common >3 yrs old, young adults ---1-6 wks after infection ---hx sore throat or impetigo 2. hematuria 3. edema 4. oliguria 5. hypertension: HA 6. possible eventual renal failure

Laboratory
1. scanty, brown urine 2. UA ---RBC’s, WBC’s, tubular cells, casts - **RBC cast is pathognomonic for Glomerular Nephritis** ---proteinuria 3. serum creatinine 4. urine creatinine clearance

Treatment
1. no specific standard tx 2. protein restriction 3. 180mg CoQ10 daily see also nephrotic syndrome